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Fire Up Those Sequencers

Bertalan Meskó blogs that "the ClinSeq project is really promising." This project is looking into the role that whole-genome sequencing can play in the clinic. The initial phase will enroll about 1,000 people who will give a family and personal medical history and will have about 300 to 400 genes related to atherosclerosis sequenced using a Sanger-based method. At SciFoo he also spoke with George Church, who told him that someone's genome can currently be sequenced for less than $5,000 and that the goal of $1,000 could be possible by the end of the year.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.