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Finding Your Name

The Genetic Genealogist has been discussing how DNA testing, particularly of the Y-chromosome, can tell men their surname. He refers to research from Mark Jobling's lab at the University of Leicester that says two men who share the same surname have a 24 percent chance of sharing a common ancestor; that chance increases if the last name is rare. In a related post, he links to a BBC article that says that male adoptees are using genetic genealogy databases for just that reason. Larry Moran says this is an ethical problem since the wishes of the two parties, adoptee and biological father, are at odds. Furthermore, testing could also reveal who is not that person's father.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.