Finding the Number

Raphael Kopan and his colleagues at Washington University in St. Louis write in Cold Spring Harbor Protocols about a pyrosequencing-based method to determine the copy number of any allele from any genome. Their approach, called reference query pyrosequencing, takes "advantage of the fact that pyrosequencing can accurately measure the molar ratio of DNA fragments in a mixture that differ by a single nucleotide," they write.

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

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In Science this week: full CRISPR locus integration complex structure, and more.