Filters and False Positives | GenomeWeb

Over at MassGenomics, Dan Koboldt discusses a talk given by Jay Shendure on applications of next-gen sequencing. One part of the talk was on “saturation mutagenesis” which Shendure’s lab is using to find “single nucleotide changes in the core promoter that alter gene transcription,” Koboldt explains, before describing the three steps of the process.

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