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Figuring Out How to See the Glycome

In PNAS, Berkeley researchers discuss how to image the glycome. Usually, glycans are identified by using antibodies or lectins bound to probes. Since those methods are not easily applied to in vivo imaging, researchers are beginning to turn to metabolic labeling and fluorescent probes, say Scott Laughlin and Carolyn Bertozzi. "A collection of such reagents would enable a more thorough analysis of how glycan patterns change during normal and pathological processes," they write.

PNAS also notes that beginning with papers submitted this month, its authors will keep the copyright to their papers and the National Academies of Science will have the exclusive right to publish it.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.