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A Few More Genes for Alzheimer's

A pair of papers published today in Nature Genetics reports on new genes associated with Alzheimer's disease, bringing the total number of genes associated with the disease to 10, The New York Times says. One group of researchers studied Europeans with Alzheimer's and the other studied Americans, and both groups homed in on similar genes. The newly unearthed genes increase a person's risk of developing the disease by about 10 percent to 15 percent — a more modest effect than that of APOE, which can raises a person's risk by 400 percent to 1,000 percent depending on the number of copies of the gene the person has, the Times adds. "If we could eliminate the detrimental effects of all 10 variants, we would eliminate 60% of Alzheimer's disease," says senior author Julie Williams from Cardiff University in the UK's Guardian.

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.