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Fast or Accurate?

Mass Genomics’ Dan Koboldt is part of the 1,000 Genomes Pilot 3 and the group is putting together a list of aligners to use. The aligners he suggested, Bowtie, Novoalign, and SHRiMP, were deemed not accurate enough, accurate but slow, and slow, respectively. And Kobolt says this points out “the key issue surrounding short read alignment for variant detection — finding the balance between speed and sensitivity.” “The ultimate short read aligner, in my opinion, would have Bowtie-like speed, Novoalign-like sensitivity, and the widespread community support that Maq enjoys,” he writes.

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.