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Fast or Accurate?

Mass Genomics’ Dan Koboldt is part of the 1,000 Genomes Pilot 3 and the group is putting together a list of aligners to use. The aligners he suggested, Bowtie, Novoalign, and SHRiMP, were deemed not accurate enough, accurate but slow, and slow, respectively. And Kobolt says this points out “the key issue surrounding short read alignment for variant detection — finding the balance between speed and sensitivity.” “The ultimate short read aligner, in my opinion, would have Bowtie-like speed, Novoalign-like sensitivity, and the widespread community support that Maq enjoys,” he writes.

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.