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Fake Rats, Real Science

The Medical College of Wisconsin won a $13 million, five-year NIH grant to build a computer model of a rat, report the Milwaukee Journal Sentinel's Mark Johnson and Kathleen Gallagher. Humans and rats share about 90 percent of their genes, including many disease genes, making the rat a useful experimental animal model. "And yet, familiar as the rat is to modern science, little exists to show the complex interplay of genes, proteins, anatomy, organ systems and environmental factors," Johnson and Gallagher say. Enter the "virtual rat" model, which the researchers hope will allow them to simulate, among other things, the animal's various biological systems. The fake rats won't replace the real things, but they will allow researchers to better design their experiments, saving time, money, and rats. Jay Bayne, executive director of the Milwaukee Institute, tells Johnson and Gallagher that this project will help scientists build experiments the way Boeing builds airplanes with computer modeling before manufacturing begins. The model will be constructed based on what's already known about the rat, but also based on observations of different strains of rats, including different kinds of knock-out rats, the reporters write.

The Scan

Push Toward Approval

The Wall Street Journal reports the US Food and Drug Administration is under pressure to grant full approval to SARS-CoV-2 vaccines.

Deer Exposure

About 40 percent of deer in a handful of US states carry antibodies to SARS-CoV-2, according to Nature News.

Millions But Not Enough

NPR reports the US is set to send 110 million SARS-CoV-2 vaccine doses abroad, but that billions are needed.

PNAS Papers on CRISPR-Edited Cancer Models, Multiple Sclerosis Neuroinflammation, Parasitic Wasps

In PNAS this week: gene-editing approach for developing cancer models, role of extracellular proteins in multiple sclerosis, and more.