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Expressing Sensitivity

Researchers at MIT found variations in gene expression that can inform clinicians about patients' response to chemotherapy. They tested how well 24 bone marrow cell lines from unrelated, healthy people grew when the cells were dosed with a chemotherapy drug. The researchers also used microarrays looked at the expression of 20,000 genes in those lines and used expression patterns to create a detection algorithm for genes associated with drug sensitivity. "This is incredibly encouraging for a clinical application," senior author Leona Samson tells Tech Review.


The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.