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Everybody Likes Faster and Cheaper

In Angewandte Chemie, Scottish researchers describe a dynamic chemistry approach to analyzing DNA, which they say would allow non-enzymatic genotyping. "This was achieved by the synthesis of a PNA [peptide nucleic acids] strand that contained a 'blank' position opposite the nucleobase under analysis in a complementary DNA template," the researchers write. In the Guardian, author Juan Diaz-Mochon says this approach would be faster and cheaper than other testing methods. "The market for DNA testing is quickly expanding as it becomes more affordable. Our method could help reach the goal of complete genome analysis in a few hours for less than $1,000," he says. Diaz-Mochon and his co-author Mark Bradley hold a patent on this concept.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.