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Even More Plants and Animals

During Tuesday morning’s plenary session, Stanford University’s Stephen Quake, who co-founded Fluidigm and Helicos BioSciences, discussed what the biological analog of the integrated circuit would be, and his lab’s work toward single-cell genetic and genomic analyses and direct deterministic phasing. Then, during a new workshop on systems genomics, researchers discussed ways genomic tools are being put to use to study organisms like medicago and rice. In particular, the University of California, Davis’ Pamela Ronald noted that her lab is using such tools to study biotic stress response in rice.

Then at the Pacific Biosciences workshop, Cold Spring Harbor Laboratory’s Michael Schatz discussed ways to assemble reads generated on the company’s RS machine, while Davis’ Simon Chan talked about his work to analyze more than 250 publicly available shotgun sequences to study centromeres. Later, Monsanto’s Todd Michael and the USDA’s Tad Sonstegard received Illumina’s Agricultural Greater Good Initiative award for their work on baobab and goats, respectively.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.