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Even Cheaper: Ask Mom and Dad

Here's an article from Discover magazine by reporter Boonsri Dickinson, who chronicles her use of DNA-based ancestry testing services. "The business of genealogy is going genetic, as entrepreneurial scientists hijack the kinds of DNA analysis previously used to determine evolutionary relationships and give them a personal spin," she writes. Dickinson signed on with the Genographic Project, tested her paternal lineage with Family Tree DNA, and became a customer of 23andMe to look at ancestry markers across her genome. Ultimately, she says, the results were not too impressive. "Clearly I had hoped for too much from the ancestry tests. In the future, DNA databases will expand and the new-style genealogists will get better at interpreting our genome," she writes. "But the events that define who we are will continue to unspool as they always have—through experience and serendipity."

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.