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Eric Schadt's Network

Pacific Biosciences's Eric Schadt doesn't want to be just a scientist, says this fast-paced Esquire piece, he wants to be a "master of information." Since the one-gene-at-a-time approach doesn't seem to be working, Schadt says, why not look at many genes and proteins and their networks? "The networks between genes and proteins turn out to be organized socially, like human networks, and so human social networks will be required to understand them ... with Eric Schadt at their center," Esquire's Tom Junod writes. Stephen Friend tells Junod that Schadt has sold biologists on complexity. "Eric gets you to understand that it's out of complexity that a pattern derives. That complexity is not the enemy but the vehicle of understanding, and embracing it is how you get there," Friend says.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.