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Emil Smith Dies

Emil Smith, a biochemist who studied proteins and chaired UCLA's department of biological chemistry, died of complications from a heart attack. He was 97. According to the Los Angeles Times, Smith along with his colleague Emanuel Margoliash uncovered the amino acid sequence of cytochrome c in the late 1950s. They then sequenced it in other mammals, finding that the human cytochrome c is identical to the chimpanzee's, differed at two positions from the rhesus monkey, and at 12 spots from the horse. Emile Zuckerkandl and Linus Pauling's idea of a molecular clock was based on Smith's work. In the late 1960s, Smith and his colleague James Bonner determined the histone H4 and showed that cows and pea plants differed at two positions. "Emil Smith was one of the true pioneers in the development of protein chemistry, particularly in the immediate decades following World War II," says UC Irvine's Ralph Bradshaw.

The Scan

Vaccine Update Recommended

A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.

US to Make More Vaccines for Monkeypox Available

The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.

Sentence Appealed

The Associated Press reports that Swedish prosecutors are appealing the sentence given to a surgeon once lauded for transplanting synthetic tracheas but then convicted of causing bodily harm.

Genome Biology Papers on COVID-19 Effector Genes, Virtual ChIP-seq, scDART

In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.