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Eighty-Seven Percent Right Isn't Too Bad

Steven Briggs reports in PNAS that about 13 percent of the Arabidopsis proteome is incomplete due to missing and incomplete gene models. He and his colleagues isolated Arabidopsis proteins, determined the amino acid sequences of 144,079 peptides by tandem mass spectrometry, and found that while 126,055 peptides resided in existing gene models, 18,024 were novel. The authors say that "much is to be gained by joining forces, and incorporating proteomic evidence upfront into the genomics pipelines."


The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.