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In This Economy, $100K Looks Awfully Good

The Wall Street Journal reports that during the next five years the Bill & Melinda Gates Foundation will give $100,000 to more than 100 scientists around the world "for research into areas that include how to prevent or cure HIV/AIDS and tuberculosis." This $100 million, issued through the foundation's new Grand Challenges Explorations, is part of an experiment to give out smaller grants to a larger number of scientists and hope that some of the high-risk research pays off. "The foundation culled the 104 grantees in the program from 4,000 applicants that filled out a two-page application over the Internet," the article says. "It encouraged experimenters to propose offbeat or novel approaches to problems."


The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.