Derek Lowe writes about the "hot" field of activity-based protein profiling, which he explains via a critique of a current paper out of Benjamin Cravatt's lab at Scripps. His paper tested the most effective ways to photoaffinity-label histone deacetylase enzymes and found that in vitro and in vivo results are not always the same. Lowe emphasizes that in drug discovery especially, assumptions should never be made.

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Two researchers have found that behavioral genetic defenses in criminal cases don't tend to affect outcomes, according to Popular Science.

Researchers report that while host genetics influence the oral microbiome, they don't appear to affect cavity-causing microbes, the Economist says.

Pandas' gut microbiomes change as what they eat changes with the seasons, writes Discover's Inkfish blog.

In PLOS this week: comparative genomic study of malaria-linked macaque parasite, search for apple root reference genes, and more.