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Is Drug Discovery Really Like Playing Poker?

Derek Lowe writes about the "hot" field of activity-based protein profiling, which he explains via a critique of a current paper out of Benjamin Cravatt's lab at Scripps. His paper tested the most effective ways to photoaffinity-label histone deacetylase enzymes and found that in vitro and in vivo results are not always the same. Lowe emphasizes that in drug discovery especially, assumptions should never be made. "If you say 'in vitro', I say 'whole cells'. If you've got it working in cells, I'll call for mice. Then I'll see your mice and raise you some dogs. Get your compounds as close to reality as you can before you pass judgment on them,” he writes at In the Pipeline.

 

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.