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A Dribble of Data

Data from the Coriell Institute's Personalized Medicine Collaborative is starting to dribble out, writes John Fossella at Genes to Brains to Mental Health. So far, Fossella has seen results on five risk variants for five different diseases and says that they line up with the data he received from 23andMe, except for one variant that 23andMe doesn't test.

In other genetic testing news, 23andMe is offering free genome scans, a total of 4,500, to participants in the Palo Alto Senior Games where all athletes are over the age of 50, says Daniel MacArthur at Genetic Future. "Basically, 23andMe is looking for the genetic secrets to a healthy, active old age, and they're willing to spend a hefty chunk of money to get it," he writes.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.