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Draft Policies

The US Presidential Commission for the Study of Bioethical Issues has finished its year-long discussion of the ethical implications of applying whole genome sequencing to genetic research and clinical care, writes Dan Klotz at the commission's blog. "The Commission's recommendations," said commission chair Amy Gutmann, "clump into two big categories, one is consent to whole genome sequencing and to the possible findings and how they will be treated, and the other is oversight."

As our sister publication GenomeWeb Daily News reports, the commission's draft recommendations "focus on the development of policies for protecting data and limiting access to it, on implementation of 'workable' informed consent policies, and on policies that facilitate the benefits of genomic data for research and the public good." At the Bioethics blog, Klotz adds that the commission plans to present its report to President Barack Obama in the fall.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.