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Don't Forget the Caveat

At in the Pipeline, Derek Lowe applies a Wired article on David Li's formula that allowed Wall Street to make vast amount of money (while overlooking the formula's limitations, which ultimately is crashing down around their ears) to drug discovery and development. Lowe says many of the examples in the Wired piece can be extended to that industry:

"What are the risks of each compound in Company X's pipeline failing? If a compound with a similar mechanism wipes out over at Company Y, how have the odds now changed? What about patent risks - if a Supreme Court decision makes everyone rethink issues of infringement or obviousness, how correlated are the patent-busting exposure around the industry? And so on…" he writes.

Lowe adds that the difference is that pharma hasn’t quite convinced itself that everything's all figured out nor has issued securities.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.