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Donald Nicholson Dies

Donald Nicholson — the Leeds medical school biochemist who mapped human metabolic pathways — has died, writes Jon Volger in The Guardian. He was 96. Nicholson detailed the interactions between enzymes and metabolites in the body, in various bodily functions and in disease, Vogler says. Before he started his work, only about 20 pathways had been charted. In 1955, Nicholson drew the first combined map of these pathways to determine how they interact. "Over the next 60 years, until just a couple of weeks before his death, he added in the huge numbers of new pathways that biochemists were discovering — currently there are thousands — and progressively improved their presentation," Vogler adds.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.