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Does That Also Affect the Number of Times They Walk in a Circle Before Lying Down?

Doberman pinschers that curl up and suck their flanks for hours — a compulsive behavior — share a gene, report researchers in Molecular Psychiatry. Nicholas Dodman and his colleagues studied the genomes and pedigrees of 94 Doberman pinschers that sucked on their flanks or on blankets, or both, with 73 Dobermans that did neither. From their genome-wide association study and fine-mapping, they found that the most significantly associated SNP is within the CDH2 gene, which mediate synaptic activity-regulated neuronal adhesion. “As little is known about the underlying molecular mechanisms for compulsive behaviors, this discovery could provide a better understanding of disease biology and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans,” the authors write.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.