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Diagnosis: Out of Tune

Gil Alterovitz, a research fellow at Harvard Medical School, has used proteomic data and mathematical modeling to develop a computer program that translates protein and gene expression into music. In his music, health is distinguished from disease by harmony. Alterovitz studied protein networks in colon cancer data, and found four key ones that he then assigned a note to. He found that "notes would form a harmonic chord in normal, healthy states and become increasingly out of tune as key physiological signs go awry, signaling disease," reports a story in Technology Review. He hopes that in the future, doctors will be able to detect disease earlier "via a musical slip into discord."

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.