British researchers report that a 16p11.2 deletion is associated with severe early-onset obesity. That deletion, as they say in Nature, includes the SH2B1 gene that is involved in leptin and insulin signaling. "This is the first evidence that copy number variants have been linked to a metabolic condition such as obesity," the Wellcome Trust Sanger Institute's Matt Hurles says in the UK's Telegraph. The Telegraph story also notes that some children in the study had been placed on the "at risk register because of fears they were being overfed" and have since been removed from the list.
Deletions and Obesity
Dec 07, 2009