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Deletions and Obesity

British researchers report that a 16p11.2 deletion is associated with severe early-onset obesity. That deletion, as they say in Nature, includes the SH2B1 gene that is involved in leptin and insulin signaling. "This is the first evidence that copy number variants have been linked to a metabolic condition such as obesity," the Wellcome Trust Sanger Institute's Matt Hurles says in the UK's Telegraph. The Telegraph story also notes that some children in the study had been placed on the "at risk register because of fears they were being overfed" and have since been removed from the list.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.