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Medical research would be much harder without animal subjects, and researchers are increasingly using animals either injected with human cells or with human tissue grafts to get a more accurate understanding of how a compound or drug works in people. A leading panel of scientists and ethicists has released a report calling for more scrutiny, regulation, and legal boundaries on this type of research, says the Guardian's Alok Jha.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.