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Deconstructing a Tumor

MIT's Technology Review reports that James Hicks and his colleagues at Cold Spring Harbor Laboratory have shown for the first time that it's possible to examine individual cells in a tumor to show the variability in its makeup. Until now, Technology Review's Lauren Gravitz reports, most tumor analysis has been done on thousands of cells at once, "a method that can obscure individual variation and can cause researchers to misidentify a cancer's aggressiveness." But Hicks' technique allows researchers to sort through and separate the cells, and amplify parts of their genome. "Once you know the different populations of cancer cells, you can use therapies that target all of them and eradicate much more of the disease," Gravitz says.

The Scan

Not Kept "Clean and Sanitary"

A Food and Drug Administration inspection uncovered problems with cross contamination at an Emergent BioSolutions facility, the Wall Street Journal reports.

Resumption Recommendation Expected

The Washington Post reports that US officials are expected to give the go-ahead to resume using Johnson & Johnson's SARS-CoV-2 vaccine.

Canada's New Budget on Science

Science writes that Canada's new budget includes funding for the life sciences, but not as much as hoped for investigator-driven research.

Nature Papers Examine Single-Cell, Multi-Omic SARS-CoV-2 Response; Flatfish Sequences; More

In Nature this week: single-cell, multi-omics analysis provides insight into COVID-19 pathogenesis, evolution of flatfish, and more.