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Charles Darwin carried out experiments on inbreeding in plants that led him to worry about the health of his children, note Francisco Ceballos and his colleagues in this month's BioScience. The researchers then examine the family trees of both Charles Darwin and his wife Emma Wedgewood, who was also his first cousin, to determine if Darwin's fears were founded — and the researchers say they were.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.