Predicting toxic drug effects in humans would go a long way toward helping doctors choose better courses of treatment for their patients and helping drug companies create better drugs, says In the Pipeline's Derek Lowe. DARPA is now soliciting proposals for the creation of a "toxicology chip," the idea being to "grow a variety of human cell lines in small, three-dimensional cultures, all on the same chip or platform, and test drug candidates across them," Lowe says.

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