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On his blog, Keith Robison walks through the history of restriction enzymes — from the use of pBR322, to the blue and white reporting colonies of β-galactosidase, to polylinkers. He suggests that biology classes look at the pUC polylinker to find all the palindromes and bioinformatics classes write a program to design a polylinker with specific endonuclease sites — and remember that the first polylinker was designed by hand, on paper.

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Kelvin Droegemeier, the director of the White House Office of Science and Technology Policy, is the new acting director of the US National Science Foundation.

An opinion piece at the Guardian discusses the state of SARS-CoV-2 testing in the UK.

Wired reports the University of California, Berkeley's Innovative Genomics Institute has transformed itself into a diagnostic lab to run SARS-CoV-2 tests.

In Nature this week: direct-capture Perturb-seq approach for combinatorial single-cell CRISPR screens, potential uses of genome-editing in breeding crops, and more.