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Conflicted Reports

BMC Genomics has issued an expression of concern regarding a 2011 article on an adaptive role for subfunctionalization in modulating the effect of gene dosage, Retraction Watch reports. According to a statement from the journal, one of the institutions to which first author Ariel Fernandez was affiliated found that the data he generated was not reproducible while a second institution he was associated with did not find anything wrong with the methods or data. "Given the conflicting conclusions of these investigations, the Editors advise the readers to interpret the data with due caution," the statement says.

Retraction Watch notes that Fernandez was affiliated with the National Research Council of Argentina, the University of Chicago, and the Morgridge Institute for Research in Wisconsin.

The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.