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'Concern' Over Another Stem Cell Paper from Harvard Lab

"Serious concerns" have been raised about a second paper coauthored by leading Harvard stem cell researcher Amy Wagers and Shane Mayack, a postdoc who worked in her lab, reports the Boston Globe's Carolyn Johnson. Earlier this week, Wagers retracted a paper she and two others coauthored with Mayack in Nature, and she has now brought concerns about a 2008 paper in Blood to the journal's editorial board, who posted a "notice of concern" regarding the paper, Johnson says. The notice states that the matter is currently under review.

Nature News' Alla Katsnelson says that when Nature reporters compared the two papers, they found what looked to be duplicate flow cytometry plots. In a statement to Nature News, Wagers says, "The integrity of the scientific process and my research is my highest priority, and I have acted to ensure that any errors in the record are fully corrected." Mayack declined to sign the retraction of the Nature paper.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.