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Coming Attractions

The BRCA1 gene — coming soon to a theater near you.

Yes, genetics has gone Hollywood in the forthcoming movie, Decoding Annie Parker, a story, according to IMDB, about "love, science, sex, infidelity, disease and comedy ... and the almost discovery of a cure for cancer."

Scheduled for release in March, Annie Parker is actually the story University of Washington geneticist Mary-Claire King's (who will be played by Helen Hunt — no word yet on whether Paul Reiser is attached) discovery of the BRCA1 gene's links to breast cancer. According to a Seattle Magazine profile of the scientist, though, King had no idea the movie was in production, only learning about it when one of her students came across it online.

"It took her awhile to convince her it wasn't a practical joke," the magazine says.

As for us, we're just trying to imagine the pitch meeting: It's like Gattaca meets Erin Brockovich crossed with Lorenzo's Oil... Also, what are the chances Myriad sues for royalties?

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.