Case Western's Neil Greenspan says his issue with Francis Collins as NIH director doesn't deal with Collins' scientific or political skills or even his religious views. Rather, Greenspan is concerned that Collins is an "irrepressible optimist", as a news story in Science recently called him. Writing in The Scientist, Greenspan goes through a few statements made by Collins that he says oversell science.

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Robert Redfield is floated as the next director of the US Centers for Disease Control and Prevention, the Washington Post reports.

The New York Times writes that the National Institutes of Health's All of Us Research Program is "ambitious" and that some are concerned it might be overly so.

Representative Lamar Smith's criticism of the National Science Foundation has "changed the nature of the conversation," according to ScienceInsider.

In PLOS this week: non-coding RNA function in yeast, transcriptomic profiles of malaria parasites, and more.