"Contamination of various sorts has plagued genome projects from the get-go," complains Keith Robison at Omics! Omics!. Doing some background searching, he found a lot of contamination in sequence data sets, including plasmids and vectors among eukaryotic sequences. He says a New Year's resolution for everyone should be to recheck sequencing pipelines. "The solution is to run filters -- search everything you do against vectors, E.coli and other common contaminants.

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