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Characterizing Adenocarcinomas

An advanced online paper from Nature characterizes copy number alterations in the lung adenocarcinoma genome. Researchers led by Eric Lander and Matthew Meyerson analyzed 371 primary lung tumors using dense SNP arrays to find 57 recurrent events. Of the 39 autosomal chromosome arms, 26 consistently had large-scale copy number gains or losses. The scientists also found 31 recurrent focal events, six of which are associated with known mutations. The most common event was an amplification of chromosome 14q13.3 which contains NK2 homeobox 1, a lineage-specific transcription factor.

 

The Scan

Vaccine Update Recommended

A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.

US to Make More Vaccines for Monkeypox Available

The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.

Sentence Appealed

The Associated Press reports that Swedish prosecutors are appealing the sentence given to a surgeon once lauded for transplanting synthetic tracheas but then convicted of causing bodily harm.

Genome Biology Papers on COVID-19 Effector Genes, Virtual ChIP-seq, scDART

In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.