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Characterizing Adenocarcinomas

An advanced online paper from Nature characterizes copy number alterations in the lung adenocarcinoma genome. Researchers led by Eric Lander and Matthew Meyerson analyzed 371 primary lung tumors using dense SNP arrays to find 57 recurrent events. Of the 39 autosomal chromosome arms, 26 consistently had large-scale copy number gains or losses. The scientists also found 31 recurrent focal events, six of which are associated with known mutations. The most common event was an amplification of chromosome 14q13.3 which contains NK2 homeobox 1, a lineage-specific transcription factor.


The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.