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Characterizing Adenocarcinomas

An advanced online paper from Nature characterizes copy number alterations in the lung adenocarcinoma genome. Researchers led by Eric Lander and Matthew Meyerson analyzed 371 primary lung tumors using dense SNP arrays to find 57 recurrent events. Of the 39 autosomal chromosome arms, 26 consistently had large-scale copy number gains or losses. The scientists also found 31 recurrent focal events, six of which are associated with known mutations. The most common event was an amplification of chromosome 14q13.3 which contains NK2 homeobox 1, a lineage-specific transcription factor.


The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.