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To Change Horses Halfway Through

The Office of Extramural Research at the US National Institutes of Health has allowed multiple investigators on grant applications since 2007 "to promote team science and multidisciplinary approaches to biomedical research," says the office's Extramural Nexus publication. Though a request for multiple principal investigators was only allowed on new or renewal applications. The policy has now been revised to allow changes mid-award. "We determined that unique circumstances may arise in which it would be in the best interest of a project to change the leadership model mid-award, and that peer review of the new leadership team and leadership plan may not be essential in these cases," the post says. The notice may be seen here.

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.