Certain Circumstances

The US Preventive Services Task Force has updated its recommendations for assessing and testing BRCA1 and BRCA2 mutations for breast and ovarian cancer susceptibility. As the task force's chair, Virginia Moyer, writes in the Annals of Internal Medicine, routine genetic screening in the absence of family history of the disease is not warranted.

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In Science this week: factors influencing retrotransposon integration sites, and more.

A bioethicist argues for the responsible use of germline gene editing.

Some breweries are using DNA-based testing to determine whether unwanted bacteria are affecting their beers, The Verge reports.

Standardized N-of-1 trials will be needed to test out personalized medicines, writes Nicholas Schork from the J. Craig Venter Institute at Nature.