Skip to main content
Premium Trial:

Request an Annual Quote

Cellular Defect Could Lead to Cancer

UCSF researchers have discovered a cellular defect that disrupts the production of proteins in human cells, and could lead to a susceptibility to cancer, they report in Cancer Cell. The researchers, led by Davide Ruggero, focused on the mTOR, which controls cell survival and proliferation. According to the researchers, when cells in the body lose the ability to control mTOR activity, the hyperactivated protein causes protein synthesis rates to climb – the cells proliferate without limit, simultaneously becoming immortal and forming tumors. But there is a solution, the researchers say. With a new drug called PP242, discovered by another UCSF lab, they were able to bring protein synthesis and cell proliferation down to normal levels by controlling mTOR activity.
The drug is currently in Phase 1 clinical trials.

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.