"Change the world by being yourself" — that's the motto of Saturday Night Live alum Amy Poehler's new website, Smart Girls at the Party. The actress, along with two other women — Meredith Walker and Amy Miles — produce short videos where they interview girls interested in STEM about their interests and projects. Take, for example, this video of Poehler with Rachel, a young girl who builds robots for fun.

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In Nature this week: genomic analysis of high-grade serous ovarian cancer, and more.

The new Riken president outlines some of his plans for the institute.

The Guardian discusses whether big science projects are worth the loss of resources available for other scientific pursuits.

An NEJM update from the ClinVar team highlights the difficulties of interpreting genetic variants.