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Derek Lowe is intrigued by NIH's latest announcement that it is beginning a preclinical drug discovery endeavor for rare diseases and says that it'll be a good learning experience for researchers to see the difficulties involved in getting a drug through the development process. He adds that the NIH, judging by its release, is clear-eyed about the process.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.