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In Case You Weren't Already Despairing

Despite more and more people being awarded science degrees, young PhDs are turning away from pursuing careers in academia, writes Sheril Kirshenbaum at Science Progress. Two recent studies, one from NIH and another from AAAS, say that young scientists are leaving due to a lack of funding and opportunities. Young investigators, says Kirshenbaum, submit twice as many grant proposals as established investigators, leaving little time to hone their scientific skills. But even getting an academic position is daunting -- the probability that someone with a PhD who is under the age of 35 will get a tenure-track position is 7 percent.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.