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The Tough Choice

Blogger William Gunn is looking for a new job and, in this post, he explains why. While finishing up his PhD, he began working for a start-up company in assay development. He says he loved the freedom but after a few months the company began to move away from his area of expertise, and with the prospect of having a child, Gunn decided to move on. "I began actively applying for positions, but at the same time I started thinking about other possible opportunities, and now I find myself with a variety of loose ends again," he blogs, though he is hopeful about joining another small biotech.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.