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Perfecting the Postdoc Application

Writing in Nature, Kendall Powell explains how to compose pristine post-doctoral applications. In speaking with senior scientists, who screen a multitude of applications per year, Powell provides readers with some straightforward “dos and don’ts.” For example, she writes that background research is essential, as are a meticulously prepared CV and cover letter. She stresses that personalization is key ― “form letters and typos will get applications nowhere,” Powell writes. Things an applicant should never do: highlight personal woes, bad-mouth previous labs, or express a desire to work only at night. She’s also arranged a “Postdoc application to-do list” in her article.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.