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It's Not Quite "Being a New PI for Dummies"

Kathy Barker's second book, At the Helm: Leading Your Laboratory, is now available in an updated second edition that focuses specifically on the challenges that new principal investigators face in getting their labs up and running. Fresh topics in the new edition include "collaboration contracts, performance evaluations, communicating with non-scientists, tips for succeeding on the tenure track, and professional development," according to a Cold Spring Harbor Press statement. "The world has changed since the first edition of 'At the Helm' was published in 2002," Barker writes, "and the laboratory has changed with it, for better and worse." Barker's content is based on interviews with PIs and their anecdotal advice.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.