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How to Lead a Leading-Edge Lab

In a blog post at Lab Management Matters, John Borchardt discusses "breaking through barriers to change" at the bench. Lab managers, he writes, foster a "static workplace culture that can reduce productivity and job satisfaction as business conditions change and both science and technology advance," when they allow their groups to succumb to "not invented here syndrome" — wherein employees look to external solutions for their problems; when they direct their staffs' efforts inappropriately — "Many managers would benefit by applying the Pareto Principle to time management," he says; and when they fail to contribute to a "sense of enjoyment" in the workplace. As people who enjoy what they're working on are more productive, Borchardt suggests that managers must truly enjoy their own work in order to encourage their colleagues to do the same.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.