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Grants as Ageism

The University of Maryland's Les Costello writes at The Scientist that NIH's initiative to support new investigators at the same rates as established investigators is a form of age discrimination. "As young investigators, I and my colleagues successfully competed with established researchers based on merit, without preferential treatment," he writes. "NIH states that in recent years young investigators have not competed successfully with established investigators, hence the need to downgrade the quality of science funded through the R01 research grant mechanism."

NIH has re-issued the call for the Director's Pioneer Awards and New Innovators Awards, The Scientist also reports. These awards for riskier research will provide $2.5 million to about 15 scientists and $1.5 million to over 30 researchers, respectively. The New Innovators Awards specifically target researchers who have yet to receive an R01 grant.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.