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The Fun of Reviewing

Keith Robison is more than happy to take on more manuscript reviews — though he adds that he wouldn’t want to do it full-time — and he discusses some of his experiences with reviewing. He writes that he enjoys is but occasionally isn’t satisfied with his reviews, particularly when he can’t quite figure out why he is “uneasy” with a paper and when he looks at a really good paper. “If the paper is truly good, you really don’t have much to do,” he says. The most satisfying ones, he says, occur when he sees a poor paper. “In most cases, there is a core of something interesting, but often either the paper is horridly organized and/or there are gaping holes in it. It can be fun to take someone's manuscript, figure out how you would rearrange & re-plan it, and then write out a description of that,” he writes.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.