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Finding Her Way

In the Washington Post, Claire Fraser-Liggett says that she went through the ordeal of applying to medical school, but then decided that research was for her. "In my senior year of college, I did research with a doctor that got me excited about what a career in medical research was all about," she says. That started her on the path to graduate work in pharmacology and then to work at NIH's Neurology Institute, focusing on G-protein-coupled receptors, and the Institute for Genomic Research. "This new opportunity allowed me to enter into genomics at a time when it hadn't really become a field. One of the things that attracted me was thinking about how to apply large-scale DNA sequencing and analysis to the receptors that I was working on," she says.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.