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Begin with the End

Over at her blog, Isis the Scientist reflects on the "best paper-writing advice" she has ever received: When composing a manuscript, it's best not to think in terms of the paper's linear format. "Instead, create the tables and figures first and organize them until you can use them to verbally tell the story. Then outline the key points of the story and organize the critical citations that support the story," she says. When it’s time to begin writing, Isis suggests starting with the results and discussion, then approaching the methods section. "Write the introduction and abstract last," she says, so as not to "lock yourself into a narrative that may not be the best fit for your data."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.