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‘Now is the Time’ for Curricular Change

In a letter published in this week's Science, HHMI professors at several US institutions express a need for curricular changes to university-level science. "Because a large fraction of undergraduate students enroll in science courses to meet the requirements for admission to medical school, courses satisfying these requirements dominate the undergraduate science curriculum," the authors write. But this isn't necessarily a good thing, in their opinion. "The prescribed course structure has impeded educational innovation, particularly the development of new, multidisciplinary courses," the authors write. "Now is the time for science faculty to convene to reconsider what all future scientists (not just medical doctors) should know and how that material should be taught in their institutions."

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.